Postdoctoral Fellow - Brenner Laboratory - Diabetes and Cancer Metabolism

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer, type 1 diabetes, type 2 diabetes and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

City of Hope has one of the most influential type 1 and type 2 diabetes research programs in the world. Our scientists' work has revolutionized the understanding and treatment of the disease and continues today with exciting developments in cell transplantation, gene regulation, immune tolerance and gaining systemic understanding of diabetes as a complex, multifaceted disease.

To learn more about our exciting research and accomplishments in the field of Diabetes, please visit https://www.cityofhope.org/research/diabetes-metabolism-research-institute

Position Summary

A postdoctoral fellowship opportunity is immediately available in the laboratory of Dr. Charles Brenner in the Diabetes and Metabolism Research Institute (DMRI) at Beckman Research Institute of City of Hope. The Brenner laboratory examines how nicotinamide adenine dinucleotide (NAD), the central regulator of metabolism, is disturbed by diseases and conditions including cancer, neuropathy, fatty liver, postpartum and viral infection. By identifying alterations in metabolism, we identify ways to sensitize and kill cancer cells, protect damaged nerves, and improve the repair capacity of damaged tissues.

The postdoctoral fellow will dissect mechanisms of transcriptional, post-translational and metabolomic alterations as a function of metabolic stress to better model and develop treatments for metabolic diseases and cancer and to support good health in the face of postpartum and viral challenges. Please read more information about the laboratory at http://brennerlab.net .

Applicants are encouraged to carefully read papers downloadable from https://www.brennerlab.net/curriculumvitae/ (eg. paper #129 on postpartum, #135 on glioma, or our recent work on coronavirus https://doi.org/10.1101/2020.04.17.047480 ). After reading one or more recent papers, applicants should propose a question, or an experiment related to work in the Brenner laboratory.

Basic education, experience and skills required for consideration:

• PhD or equivalent doctoral degree is required.
• Creative work as documented by peer reviewed publications.
• Applicants are encouraged to carefully read papers downloadable from https://www.brennerlab.net/curriculumvitae/ (eg. paper #129 on postpartum, #135 on glioma, or our recent work on coronavirus https://doi.org/10.1101/2020.04.17.047480 ). After reading one or more recent papers, applicants should propose a question, or an experiment related to work in the Brenner laboratory.

Additional Information:

• Interested candidates should include a letter describing past accomplishments and future research interests, a CV, and a question/experiment related to the work in Dr. Brenner's laboratory
• For more information on Dr. Charles Brenner's research please visit here
• To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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• Posting Date: Jun 4, 2021
• Job Field: Research
• Employee Status: Regular
• Shift: Day Job