Postdoctoral Fellow - Immunotherapy for Oncogenic Herpesvirus

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow.

Our laboratory invites highly motivated candidates to apply for an interdisciplinary postdoctoral scholar position. Our laboratory focuses on oncogenic herpesviruses, in particular Epstein-Barr virus (EBV), Kaposi-sarcoma associated herpesvirus (KSHV), and the rhesus macaque EBV homologue rhesus lymphocryptovirus (rhLCV), and on developing prophylactic and therapeutic strategies against primary infection with these viruses and their associated cancers. The postdoctoral scholar will be working on projects with the overarching goal of designing and testing gamma herpesvirus vaccine candidates and immuno-therapeutics in various preclinical animal models.

The scholar will be leading projects that are in collaborations between the City of Hope Cancer Center and other institutions within and outside the USA. Importantly, City of Hope has good laboratory practice (GLP) and Current Good Manufacturing Practice (cGMP) FDA-approved biologic facilities ( https://www.cityofhope.org/research/biological-and-cellular-gmp-manufacturing-facility/cbg---center-for-biomedicine-and-genetics ) to produce the candidate vaccines and immunotherapeutics in house and test them in preclinical animal models and in Phase I clinical trials.

Basic education, experience and skills required for consideration:

• A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
• Molecular biology, protein expression, purification, crystallization, and functionalization
• Generation and characterization of monoclonal antibodies for diagnostic and therapeutic purposes
• In vitro methods for assessing immunological responses, particularly antibody assays (such as ELISA, isolation/depletion of antigen-specific antibodies, viral neutralization assays, etc), T cell response and toxicity assays.
• In vivo immunization and/or tumor investigations, specifically murine (transgenic and humanized), rabbit and NHP models.
• Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner
• Ability to participate in the preparation of grant applications, scientific publications and investigational new drug applications

Additional Information:

• For more information about Ogembo's lab, please visit https://www.cityofhope.org/research/beckman-research-institute/research-departments-and-divisions/immuno-oncology/javier-gordon-ogembo-lab
• To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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• Posting Date: Dec 14, 2021
• Job Field: Research
• Employee Status: Regular
• Shift: Day Job