Principal Associate Scientist, DMPK / Bioanalytical

Generation Bio is seeking a highly motivated, energetic, and enthusiastic scientist to join our rapidly growing DMPK/bioanalytical team to support preclinical and early clinical development phases of non-viral vector-based gene therapies. We are seeking an exceptional individual to fill this critical role in our organization where you will be part of a versatile, fast-paced, and collaborative team. The primary job responsibilities include: 1) developing bioanalytical methods using molecular assays such as: (RT)-qPCR, ddPCR, NGS etc. to support in vivo studies 2) routine analysis of in vitro and in vivo samples with appropriate methods and the generation of study reports  3) leading novel assay development projects 4) collaborating with cross-functional teams and 5) mentoring of junior team members.  This is a significant learning opportunity and the candidate is expected to be an independent thinker, a self-starter, and someone who is not afraid to push the boundaries of science. The job responsibilities also include working closely with CRO’s to transfer assays, providing scientific oversight for externally sourced studies, and ensuring seamless execution in collaboration with our Operations team. Significant cross functional interactions are required with key partnerships between Pharmacology, Toxicology, Formulation and other departments.

RESPONSIBILITIES:

·       Design, optimize, and execute assays to assess drug concentration from in vitro and in vivo samples, in various biological matrices via qPCR and/or other molecular techniques

Help build the bioanalytical function and support early career colleagues

·       Employ cutting edge technologies to understand pharmacokinetics and tissue distribution of gene therapy products

·       Scientific oversight of CRO activities for outsourced studies including method transfer, data quality and analysis

·       Design experiments, analyze data & interpret results

·       Summarize studies in written reports and oral presentations

REQUIREMENTS:

·       PhD with a minimum of 2 years or a Masters with a minimum of 6 years experience in molecular biology, cell biology, or related discipline

·       Biotech and/or pharmaceutical industry experience is preferred

·       Experience in developing bioanalytical assays, excellent lab skills and ability to work independently to analyze, interpret, and present data

·       Ability to support multiple projects across platform

·       Ability to work in a matrixed environment

·       Experience with cell lines, primary hepatocytes, a plus

·       Organized, excellent communication skills, collaborative, team player mindset

POSITION: Full-Time, Exempt