Principal Scientist

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Principal Scientist as part of the Research and Early Development team based in Piscataway, NJ. 

Role Overview

Legend Biotechnology is at the forefront of developing innovative cell-based therapies. We are seeking an experienced and dynamic principal scientist to support our in vivo CAR-T cell therapy program. If you're passionate about advancing groundbreaking treatments and have a strong background in cellular immunotherapy, this role is for you. The successful candidate should possess extensive knowledge and research experience in cell therapy and cancer biology. The candidate should have comprehensive understanding of tumorigenesis, TME, and immunotherapy. Experience with in vivo tissue/cell-specific gene delivery in animal model is preferred. The candidate will be able to contribute to developing in vivo cell therapy platform through vector design, in vitro function assay, and assay development of virus PK and PD in animal model. Nano/viral particle characterization using cytometry is a plus. 3-5 year biotech or pharmaceutical industry is preferred.

You will collaborate with team members and cross-functional teams, including research, development, and manufacturing, to drive the successful translation of preclinical findings into clinical applications. Your expertise will be critical in advancing our mission to improve patient outcomes. The candidate needs to demonstrate the ability of delivering scientific results with integrity and meeting timeline, show the value of collaboration and teamwork, and provide expertise and team support in a fast-paced environment.

Key Responsibilities  

• Develop cell and gene therapy platform and optimize cell-based immunoassays, including vector design, VLP design, virus packaging and titering, immune cell isolation and expansion, multi-color flow cytometry, ELISA, cytotoxic assays, VCN analysis.
• Design experiment to optimize process parameters, enhance cell engineering and manufacturing capacity.
• Independently design and execute experiments, document and interpret scientific results, present the data to cross-functional teams
• Stay alert to industry development, good sense of new tech/platform in the field
• Deliver result to meet timeline with accountability
• Lab support work

• Education: PhD in virology /Immunology / cell biology, or master with extensive experience.
• Experience: 3-5 year biotech or pharmaceutical industry is preferred and 2-3 years of industry experience in cell and gene therapy is preferred.
• Key Capabilities, Knowledge, and Skills: Molecular biology, vector design, gene-editing, animal model.

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.