Principal Scientist
Company
Arranta Bio
Location
Watertown
Type
Full Time
Job Description
ReciBioPharm, the biologics business unit of Recipharm AB, is a visionary contract development and manufacturing organization (CDMO) that partners with companies seeking to develop and manufacture complex biological drugs and innovative therapies. Our dedicated team, state-of-the-art facilities, and unparalleled resources are crucial for advancing products from development to commercial launch. Our vision is to be the trusted and innovative CDMO partner for advanced therapy pioneers, so that we can bring life-changing therapeutics to patients. We partner with our clients to make treatments that can benefit vast patient populations, working across many indications. ReciBioPharm’s mission is to change healthcare through our intrepid and daring team engaging with clients to develop, manufacture, and supply breakthrough therapies that transform lives.Â
JOB SUMMARY
The Principal Scientist will identify and implement the Analytical Development methodologies employed for nucleic acid based platforms and provide technical expertise to a team of scientists performing plasmid and RNA based method development. The Principal Scientist will design, perform, and interpret complex experiments supporting establishing robust, qualifiable methods for transfer to GMP. The Principal Scientist will also be responsible for technical/ scientific aspects of analytical development as well as organizational leadership including training, leading and continuously improving the analytical team. The Principal Scientist will demonstrate a sense of urgency while maintaining respect for best practices and understanding the importance and applicability of quality and controls in development activities. The problem solving, data analysis and interpretation will be focused, data driven and result in thorough documentation and pointed technical reports suitable for executive management. The Principal Scientist will be well versed in internal and external best practices, lead internal and external projects, and be the technical expert in interactions with company colleagues.  It is expected the Principal Scientist will continuously improve operational effectiveness and participate actively in the recruitment of technical staff to maintain an effective level of technical ability for all business requirements. |
ESSENTIAL JOB FUNCTION
- Develop and qualify highly sensitive, reliable, and robust LC-MS methods for the analysis of biological, viral vector and RNA modalities for early/late-stage clinical development and commercial supply.
- Perform LC-MS analysis (Liquid chromatography–mass spectrometry) for analysis of lipid impurity characterization, mRNA sequence determination e.g. Capping efficiency and Poly-A tail analysis.
- Design of cleavage probe sequences needed for execution of capping efficiency assays.
- Develop analytical characterization methods and perform testing for mRNA drug substance and mRNA-LNP drug product.
- Establish and maintain an understanding of current trends and emerging analytical technologies.
- Design key experiments and execute key analytical assays.
- Support tech transfer to internal Quality Control operations.
- Author technical development reports, tech transfer documents.
- Mentor junior team members and support expansion of Analytical Development team.
- Ensure Analytical Development deliverables are met in a timely manner.
- PhD or MSc. degree in Analytical Chemistry, Biology, Biochemistry or related sciences.
- Expert knowledge in analytical methods for characterizing oligonucleotides.
- Extensive knowledge in Waters LC/LC-MS instruments along with Empower and UNIFI software.
- Strong sense of responsibility, strong work ethic, self-motivated attitude and teamwork orientation is an absolute must.
- Ability to multitask, strategically and tactically.
- PhD with 6+ years or MSc with at least 10+ years of pharma/biotech industry experience.
- Prior experience with designing cleavage probes
- Excellent verbal and written communications skills are required.
- Ability to independently design experiments, analyze complex data and interpret and present experimental results is required.
- Will interpret and carry out an extensive variety of technical instructions in written, oral, schedule, mathematical or diagram form
- Ability to define problems, collect data, establish facts and draw valid conclusions
PHYSICAL DEMANDS
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
- Employee will be required to move around the work site using pathways/ramps providedÂ
- Communicating with others to exchange information  Â
- Use of office equipment such as computers, telephones and filing systems will be required to fulfil dutiesÂ
Who We Are
ReciBioPharm hires people who are committed and passionate to the goal of bringing life enhancing products to patients. We want top talent who will render ideas and a relentless desire towards accomplishing our mission; when a job becomes a passion, it makes you feel ALIVE.
Here at ReciBioPharm, we embrace ALIVE – our core values that we live and breathe daily! We are Agile, Leading, Innovating, Value Creating, and Engaging. Are you ready to come ALIVE with a daring and intrepid team?  Don’t wait another minute; Apply today!
MEDICAL REQUIREMENTS
- This position requires a criminal background check and drug screening.
- COVID19 Vaccine required to come on site; Individuals seeking an exemption from this requirement for medical or religious reasons should reach out to Human Resources for an accommodation.
Benefits
ReciBioPharm offers a very competitive benefits package including medical, dental, vision, prescription drug coverage, life and disability insurance, 401(k), and generous vacation and time off policies among other attractive benefits. We operate in a world class facility to attract the best and brightest talent to work collaboratively in our mission to bring novel therapies to the patients who need them most.
ReciBioPharm is an Equal Opportunity Employer.
Date Posted
05/09/2023
Views
13
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