Research Associate II

Who we are...

Cell Signaling Technology (CST) is a different kind of life sciences company, one founded, owned, and run by active research scientists, with the highest standards of product and service quality, technological innovation, and scientific rigor for over 20 years. We consistently provide fellow scientists around the globe with best-in-class products and services to fuel their quests for discovery.

Helping researchers find new solutions is our main mission every day, but it's not our only mission. We're also dedicated to helping identify solutions to other problems facing our world. We believe that all businesses must be responsible and work in partnership with local communities, while seeking to minimize their environmental impact. That's why we joined 1% for the Planet as its first life science member, and have committed to achieving net-zero emissions by 2029.

The role...

The Research Associate is a member of the Monoclonal Antibody Development team which is a core function for antibody development at CST. This individual will be responsible for performing automated SCPD and XMT ELISA and screening XMT and mouse fusions to provide monoclonal antibody clones with the best utilities possible to be developed into final products.for screening XMT and mouse fusions to provide monoclonal antibody clones with the best utilities possible to be developed into final products. This position will focus on an early step in our product development process and will enable broad exposure to the full monoclonal antibody development process. At appropriate time this individual will rotate to another role of the team, namely the Fuser (Immortalization) Role.

You'll have the opportunity to...

• Coat ELISA plates for XMT and SCPD pipelines with robots or manually
• Run XMT ELISA semi-automatically
• Run SCPD ELISA using automated Workcell or manually when necessary
• Act as the point of contact with Automation Group and work closely with the Group to resolve issues surrounding SCPD ELISA automation
• Contribute to team’s goal of achieving highest possible screen success rate for XMT and mouse fusions as defined by percentage of XMT/mouse fusions resulting in cloning requests filed by Antibody Development Scientists
• Take over XMT or mouse fusion cultures from XMT or fusion performer 
• Feed cultures to maintain optimal cell growth conditions to obtain maximum number of XMT or fusion colonies 
• Maintain appropriate CO2 levels, temperature, and water level of assigned incubators 
• Conduct periodic cleaning and decontamination of assigned biosafety cabinet and incubator(s) to ensure that cultures are free of microorganism contamination 
• Provide XMT or fusion culture supernatants to Antibody Discovery Verticals and/or Clinical Application Testing Groups to facilitate western and applications testing 
• Meet all internal service level agreements in turnaround time to release the requested clones to Recombinant Cloning Group and Antibody Production Group for further product development 
• Purge unwanted frozen cultures in LN2 tanks and effectively manage existing LN2 storage spaces to ensure efficient productivity 
• Participate in tissue culture room restocking and recycling 
• Process and document resulting data in accordance with CST hard copy and electronic laboratory documentation requirements (e.g. notebooks, electronic LIMS, Jira, PDP, PLM, etc.)

Who you are and what you bring to the team...

• BS degree in a biological science with a minimum 2 years experience; or MS degree in a biological science with 0 - 1 years experience. (e.g. cell biology, immunology, biochemistry, molecular biology, or biotechnology) 
• Basic understanding and working knowledge of experimental design and protocols Some hands on or class experience/exposure with tissue culture Computer proficiency including working knowledge of MS Office Suite, Google Docs, or related applications 
• Strong written and oral communication skills 
• Demonstrated ability to work in a fast-paced, deadline-driven environment
• Proven effective team contributor 
• Attention to detail
• Demonstrated organizational skills 
• Early morning attendance capability

Ideally you'll have...

• Degree in cell biology or immunology. 
• Basic scientific understanding and application of fundamental biological experiments
• Knowledge in signal transduction is desirable 
• Ability to analyze and problem solve
• Advanced Excel skills (e.g. function writing and page referencing) 
• Early morning attendance capability

What we offer....