Scientist/Senior Scientist, Bioanalytical Sciences (Immunology)

About Voyager

Voyager Therapeutics (Nasdaq: VYGR) is a biotechnology company dedicated to breaking through barriers in gene therapy and neurology. The potential of both disciplines has been constrained by delivery challenges; Voyager is leveraging innovative expertise in capsid discovery and deep neuropharmacology capabilities to address these constraints. Voyager’s TRACER AAV capsid discovery platform has generated novel capsids with high target delivery and blood-brain barrier penetration at low doses, potentially addressing the narrow therapeutic window associated with conventional gene therapy delivery vectors. This platform is fueling alliances with Pfizer Inc., Novartis and Neurocrine Biosciences as well as multiple programs in Voyager’s own pipeline. Voyager’s pipeline includes preclinical programs in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS), each with validated targets and biomarkers to enable a path to rapid potential proof-of-biology. For more information, visit www.voyagertherapeutics.com

Job Summary:

As part of our ongoing expansion, we are seeking an initiative-taking and experienced Scientist / Senior Scientist to join our Bioanalytical Sciences team. This is an ideal position for an individual with a desire to innovate and with a strong background in the development of immunological and bioanalytical assays relevant to AAV Gene Therapy and Therapeutic Antibodies. This is a bench level position with an opportunity to interact with Voyager scientists in a cross-functional environment.

Key Responsibilities:

• Develop immunological and bioanalytical assays to assess immune status of preclinical study subjects in AAV gene therapy studies
• Analyze serum and/or plasma samples for the estimation of anti-AAV total antibody (Tab) and neutralizing antibody (Nab) levels
• Identify, evaluate, and implement cutting edge tools and novel immunological methods relevant to AAV gene therapy development
• Independently analyze and interpret data and present in various team formats
• Integrate and collaborate with internal research teams in a fast-paced environment
• Use best practices in the development of standardized procedures and automation systems
• Transfer immunological and bioanalytical methods to CRO labs and monitor method validation and GLP / GCP sample analyses in those labs

Qualifications

• Bachelor’s or Master’s degree in Molecular / Cellular Biology, Biochemistry, Immunology or a similar field with 8+ years of relevant experience or PhD with 0-2+ year relevant experience in biotechnology industry
• Must have deep expertise and extensive experience in diverse immunoassay platforms including, various ELISA formats (traditional, MSD, AlphaLisa, Simoa), and functional activity assays
• Expertise in development of cell-based assays and superior cell culture skill
• Independently motivated, meticulous scientist with excellent critical thinking and problem- solving skills
• Excellent people skills including written and verbal communication
• Ability to be highly productive in a collaborative and matrixed team environment
• Must be organized and able to contribute to multiple parallel workstreams
• Proficiency with Excel, SoftMax Pro, GraphPad Prism, JMP, etc.

Preferred Experiences

• Broad knowledge of Immunology
• Experience in cellular immunity assays such as ELISpot
• Knowledge of Complement activation assays
• Experience in viral gene therapy bioanalytic techniques
• Skills in various PCR techniques
• Experience in GLP and GCLP as applicable to bioanalysis
• Understanding of statistical principles as applicable in bioanalytical data analysis