Senior Associate Scientist

Alpine Immune Sciences is a leading clinical-stage biopharmaceutical company dedicated to discovering and developing innovative, protein-based immunotherapies for autoimmune and inflammatory diseases. Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!

We are looking for a Senior Associate Scientist with a solid laboratory background in a fast-paced biotechnology environment. The new team member will be part of a group charged with the delivery of high-quality research reagents to support in vitro and in vivo experiments and well-characterized potential lead candidate and clinical candidate proteins to support preclinical studies.

•Carry and maintain HEK293 and ExpiCHO cell lines.

•Banking cell lines

•Support recombinant protein expression via transient transfection. 

•Generate protein reagents for in-vitro testing by small scale expression and purification to support early-stage discovery programs.

•Database entry and protein request tracking and fulfil requests for protein dilutions.

•Designing, implementing, and troubleshooting experiments for transfection efficiency

•Perform analytical assays, such as Fortebio binding, to quantify transfection efficiency.

•Managing and maintaining lab equipment and supplies/lab operations support

•Maintain electronic lab notebook.

•Knowledge and ability to do stable CHO cell line development, a plus

•At least 2-5 years of cell culture and sterile hood techniques.

•BS in the biological sciences minimum. Industry experience strongly preferred.

•Attention to detail, with a mindset to carefully track results.

•Ability to clearly present and explain results.

•Motivated to perform precision bench work.

•Quick learner

•Energetic and flexible as needed for a rapidly evolving biotherapeutic company with eagerness to contribute to other activities outside of immediate responsibilities.

•Strong working knowledge of Microsoft PowerPoint and Excel

•Database experience is a plus.

#LI-Onsite

Alpinists share a passion for meaningful work and are committed to solving the most complex problems in immunology to create new therapies for patients. We believe in innovative thinking, collaboration, flexibility, bias for action, and healthy debate. To foster our team of outstanding scientists and business professionals, we provide a premier work environment with a state-of-the-art lab and office spaces with truly inspiring views, and an open design to facilitate teamwork.

Our treasured culture has been shaped by our diverse team who truly enjoys working and playing together. We nurture Alpine’s culture in many ways, including all-company social events and happy hours, lunch-and-learn and education opportunities, interest groups like book club and movie nights, peer-to-peer recognition programs, a robust wellness program to help support physical, mental, and emotional health, and more.

Alpine is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Alpine is also committed to compliance with all fair employment practices regarding citizenship and immigration status.

Our office and lab are located in the blossoming biotech neighborhood of Eastlake in Seattle. Alpinists enjoy the flexibility to work onsite, remotely, or a hybrid schedule, with evolving options as we prioritize keeping Alpinists safe and healthy. Onsite employees enjoy an open-office layout with comfortable huddle rooms and Zoom Room-enabled conference rooms, a spacious breakroom and kitchen with a coffee bar and snacks, and rooftop access to enjoy gorgeous views of Lake Union and Gas Works Park.

Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!