Senior Scientist II

SUMMARY/JOB PURPOSE:

Discovery Biotherapeutics is seeking a motivated Senior Scientist II of Translational Biology to provide preclinical bioanalytical support for the advancement of the biologics portfolio at Exelixis. The successful candidate must have strong bioanalytical background as s/he will support preclinical activities of ongoing and new biologics projects in antibody drug conjugates and bispecific antibodies.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Design, implement and oversee assay development, execution of pharmacokinetic sample analyses in support of proof-of-concept studies on biologic oncology programs from discovery to lead selection. 

• Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house as needed.

• Critical scientific/technical data analysis and interpretation of experiments.

• Interacts and collaborates with internal departments to deliver quality and timely findings in support of drug candidate advancement.

• Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams.

• Contribute to other translational biology efforts

• Follows company intellectual property and compliance policies and practices.

• Complies with company health and safety policies and general laboratory practices.

SUPERVISORY RESPONSIBILITIES:

• Directing work to a CRO, Consultant, or 3rd party as necessary

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

·Bachelor’s degree in pharmacology or cancer biology or closely related discipline and a minimum of nine (9) years of related experience; or

·Master’s degree in pharmacology or cancer biology or closely related discipline and a minimum of seven (7) years of related experience; or

·PhD degree in pharmacology or cancer biology or closely related discipline and a minimum of two (2) years of related experience is preferred; or

·Equivalent combination of education and experience.

Experience: 

• Experience in assay development with various immunoassay platforms for bioanalytical assays is essential.

• Previous bioanalytical experience working with ADCs and bispecific antibodies is preferred.

• Strong scientific understanding of in vitro and in vivo pharmacology, PK, and PD concepts in cancer biology is essential.

Knowledge/Skills:

• Demonstrated drive for rigorous scientific excellence. Ability to think critically and creatively to identify and solve scientific problems.

• Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously.

• Knowledge and familiarity in LC-MS-based bioanalysis is preferred

• Knowledge in using oncology-based in vivo models for drug discovery is a plus. 

• Excellent written, oral, and interpersonal communication skills. 

• A strong team player.

• Advanced knowledge in Excel, Word, PowerPoint, PDF, GraphPad prism.

• Good tracking record and report writing.

WORKING CONDITIONS:

·Environment: primarily working in laboratories or in office

·Exposures encountered, such as hazardous materials, and extreme cold.

·Travel required (up to 10%)

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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

Our compensation reflects the cost of labor across several U.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this position is $125,000 - $176,500 annually. The base pay range may take into account the candidate’s geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate’s geographic region, job-related knowledge, skills, experience and internal equity, among other factors.

In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.

DISCLAIMER 
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.