Postdoctoral Research Fellow, BioMedicine Design

What You Will Achieve
This is an exciting opportunity to join the BioMedicine Design (BMD) group at La Jolla, CA. We are seeking a highly driven and innovative Ph.D.-level scientist to join our Biotherapeutics Discovery group as Postdoctoral Research Fellow in driving therapeutic innovation through technology development in the field of CAR signaling. This is a unique opportunity to be trained at the interface of protein engineering, cell biology, and immunology, to work collaboratively with diverse research teams within Pfizer, and to publish at high-impact journals. By the end of the program, the Postdoc will be proficient in protein design, cell engineering, cellular assays, and will be fully prepared to contribute to early-stage target identification and therapeutic modality selection. The ideal candidate should have solid training in molecular biology, cell biology, immunology, or synthetic biology and good understanding of biology/oncology.
How You Will Achieve it
Successful candidates will be expected to:

• Demonstrate strong technical and scientific rigor in project planning and gap identification
• Proactively conduct literature search to gather relevant information to form hypothesis for testing experimentally
• Design and produce constructs to further our understanding of underlying biology and mechanism of action; develop and utilize cell-based assays to test hypothesis and screen and rank molecules
• Generate and effectively communicate results regularly at internal meetings, make data-driven decisions in shaping direction of research project
• Participate in developing creative approaches to discover and optimize therapeutics

Qualifications
Must-Have

• PhD in immunology, molecular or cellular biology, biochemistry, chemical engineering, synthetic biology or a related discipline is required
• Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal
• Willingness to make a minimum 2-year commitment
• No more than 2 years of post-degree experience.
• Technically proficient in (at least) some molecular and cell biology tools, including construct design, molecular biology, mammalian cell culture and cell line engineering, RNA synthesis and purification, cell line transfection and characterization, development of cell-based assays (e.g. cytotoxicity proliferation, cytokine production), and/or flow cytometry
• Proficient with data reporting and analysis software, strong planning and organizational skills
• Strong motivation, passion and commitment to science and engineering of novel entities
• Ability and desire to multitask and work in a fast-paced, interdisciplinary scientific team both independently and as part of a team, strong problem-solving and analytical skills
• Excellent written and oral communication skills

Preferred Qualifications:

• Experience with CAR signaling, cell therapy, synthetic biology, and/or synthetic receptor field is preferred
• Training in immunology and cell biology is highly desirable, prior experience with primary cell culture and functional screening of immune cells
• Understanding of immune signaling pathways and proteome mapping is a plus

OTHER JOB DETAILS

• Must have work authorization in the US.
• Work Location Assignment: On Premise. On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

The annual base salary for this position ranges from $60,900.00 to $104,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
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