Scientist- Downstream Process Development

Landmark Bio translates groundbreaking research into life-changing medicines. We provide development, manufacturing, and regulatory capabilities to help early-stage life science innovators rapidly progress advanced therapies from bench to clinic. Launched in 2021, and based in Watertown, Mass. Landmark Bio is an unprecedented venture bringing together the best of industry, academia and research hospitals to accelerate life sciences innovation. A public benefit company, our work advances emerging technologies, demonstrates therapeutic potential, and improves human health.

We are seeking a highly motivated and team-oriented professional with entrepreneurial spirit to join our company! This is an exciting opportunity for a well-qualified candidate to join a rapidly growing company focused on turning today’s cutting-edge research into tomorrow’s breakthrough therapies.

Responsibilities:

· Design and optimize downstream purification processes, leveraging advanced harvest, clarification, concentration, chromatography, and polishing techniques for lentiviral vectors, AAV, extracellular vesicles, cellular therapies, and other modalities.

· Ability to improve processes for product purity, recovery, impurity removal, and cost reduction.

· Draft, review, and refine development documents and reports

· Work closely with upstream scientists and analytical groups to ensure the highest standards of product potency, and overall quality.

· Support the tech transfer of the process to MFG team.

· This is a hands-on lab-based position requiring a flexible schedule based on experimental work (some weekend work may be required).

Required qualifications:

· B.Sc. or M.Sc. in chemical engineering, biology, biotechnology, or related discipline.

· Over 8 years of specialized experience in downstream processing with a strong emphasis on viral vector production.

· Proficient in advanced purification techniques such as affinity and anion exchange chromatography, with extensive experience operating AKTA chromatography systems and utilizing Unicorn software.

· Broad experience with filtration-based unit operations such as tangential flow filtration, sterile filtration, and depth filtration.

· Experience in scaling up and scaling down downstream processes for viral vectors or biologics. 

· Preferred if familiar with SPTFF, TFDF, and viral clearance processes.

· Strong team worker who is also independently motivated, detail oriented and possesses good problem-solving capabilities.

· Excellent organizational skills.

· Strong verbal and written skills; able to handle confidential information and material appropriately

Landmark Bio is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply.