Scientist, Discovery

We are seeking a Scientist, Discovery. The desired candidate - who will report to our Senior Director, Discovery Neurology - will be responsible for executing biochemical and cellular assays to support drug discovery efforts. The ideal candidate will be experienced with the testing of chemical compounds, data analysis and reporting results and conclusions to support lead identification and optimization. Experience in CNS drug discovery a plus. Candidates should be comfortable working in a fast-paced, dynamic, and team-oriented environment.

• Work closely with biology and chemistry teams to design and test novel peptides for non-muscle delivery and advance EDO platform.
• Establish cellular and biochemical assays to elucidate the mechanism of action of next-generation peptides in different cellular contexts.
• Design and execute biochemical and cell-based high-throughput assays and implement rigorous data analysis techniques to identify lead molecules.
• Perform molecular techniques including DNA/RNA isolation, PCR, qRT-PCR, gene expression analysis, cell line engineering and tissue culture as needed.
• Identify and characterize target-appropriate cell models for proof-of-concept analysis.
• Manage assay development, quality control and data handling by CROs.
• Collaborate effectively with internal colleagues and effectively communicate data and ideas to team members.
• Deliver clear summaries of research findings to Project Review meetings.
• Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols. 
• Highly motivated scientist with ability to multitask and prioritize work. Demonstrate ability to thrive in a fast-paced environment.
• Directly manage and oversee projects and timelines for associate scientists.

SKILLS AND COMPETENCIES

• Ph.D. in one of the following: molecular biology, cell biology, neuroscience, biochemistry with minimum 2+ years of postdoctoral experience in academia or industry settings
• Demonstrated experience with in vitro cell-based assay development and execution
• Hands-on experience in tissue culture, plate-based assays, RNA isolation, gene expression analysis (qPCR), western blot, ELISA, multiplex protein analysis, flow cytometry preferred
• Experience in neuromuscular and/or CNS drug discovery preferred
• Experience with hands on and/or managing in vivo work at CROs is a plus
• Experience with managing CROs and academic collaborations preferred
• Self-motivation, ability to work independently, excellent organization skills, multitasking and working within timelines is required
• Ability to learn rapidly, adapt and exercise flexibility for changing platform needs, workflows and projects is required.
• Good verbal, written and presentation communication skills, as well as excellent interdisciplinary and interpersonal skills with the ability to work in a team environment.
• Familiar with Microsoft Office programs and data analysis software such as GraphPad Prism.

Skills: Project Planning • Project Management • Protein Assays • siRNA • Oligonucleotides • Biomarkers • Assay Development • PCR • Molecular Biology • RNA • Immunoprecipitation • ELISA • miRNA • SIMOA • MSD ELISA

ABOUT OUR TEAM

We are a team of passionate and creative scientists committed to drug discovery. We value open and honest communication and strong research ethics. We are looking to round out our group with another team player who shares our values and help us explore the potential of our EDO platform and advance the next generation of drug candidates.

ABOUT OUR COMPANY

We are a biotechnology company advancing next-generation oligonucleotide therapies for neuromuscular and neurological diseases. Our ambition is to unlock the potential of nucleic acid therapeutics by leveraging the drug delivery capabilities of our proprietary Enhanced Delivery Oligonucleotide (EDO) platform. We are applying this technology across a wide range of indications and are rapidly growing our team at our U.S. headquarters in Boston, Massachusetts. 

EEO Statement: PepGen is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

Recruitment & Staffing Agencies: PepGen does not accept unsolicited agency resumes. Agency resumes will only be accepted if the agency is formally engaged by PepGen Human Resources.