Scientist I/II, LNP

Company Overview

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer and Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom

Position Summary

The candidate will be leading our efforts in the design and execution of novel and existing lipid nanoparticle (LNP) formulations to help advance our non-viral delivery platform and take next-gen editing modalities for bespoke indications from concept to clinical application. We are searching for a driven, enthusiastic, and self-motivated individual who is comfortable multitasking and working independently as well as part of a larger team on various aspects of in-vivo delivery. This individual will join the dynamic, rapidly growing, and highly collaborative CRISPR-X division.

Responsibilities

• Design, optimize, and execute LNP formulations for a variety of compositions and payloads with minimal supervision
• Determine key formulation parameters to provide reproducible and effective LNPs.
• Lead the production and characterization of LNPs for various studies enabling a clinical applications.
• Work collaboratively with scientists across the organization to advance company goals and enhance the understanding of LNP function.
• Be highly organized and meticulous in documenting results in electronic lab notebooks, and present findings to the broader team.
• Effectively multitask and manage multiple projects simultaneously.
• Stay up to date on in-vivo delivery literature and industrial practice.

Minimum Qualifications

• Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, Organic Chemistry, or related field and
  • Scientist I: 0-2 years of relevant experience
  • Scientist II: 2-5+ years of relevant experience
• Extensive hands-on experience and deep expertise in formulating LNPs for gene editing applications in human health.
• Hands on experience with HPLC, DLS, Ribogreen, TEM and other analytical methods.
• Pays great attention to details in the quality and reproducibility of the LNPs
• Strong communication and troubleshooting skills.
• A team player with strong interpersonal skills, and ability to collaborate effectively with others.

Preferred Qualifications

• Prior experience in LNP conjugation chemistries for drug delivery
• Prior experience in using LNPs in mammalian cell culture and animal models.

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.